SpamPal
I use SpamPal to filter spam. I use it with the Bayesian Plugin, the HTMLModify Plugin and the Whitelist Extender Plugin to block spam. I use outbound smtp proxy to auto whitelist people I send mail to. I have also made an IP Blacklist that you can copy and paste it into Blacklists/I.P.Addresses. The list is intended for spamfilters. For more general use I have another slightly different list here.
I'm very happy with SpamPal and I'm now very close to 100% accurate detection.